BCH 261 Lecture Notes - Lecture 8: Sequence Alignment, Myoglobin, Valine

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30 Nov 2020
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Proteins with similar structure & functions can have similar primary structure. Law of evolution proteins w/ similar structure & functions. Proteins are constantly made differently b/c their genes are getting mutated. Similar a. a. = a. a that fall under same classification (ex. (+)ly charged; ex. Leucince & valine are similar a. a b/c they"re both non-polar) Can predict that they have similar functions, thus switching leu to. Blast alignment between human myoglobin and human a globin sequences. The sequence of myoglobin (mb) appears above that for the a globin. Between them are shown the identical amino acids (blue) and those that are considered similar (green + ). Gaps in the alignment are shown by red text and red dashes. In this alignment there is 25% sequence identity, suggesting a high degree of structural similarity between the proteins. The expect score in this case is very low (6 * 10-6), indicating that the alignment is statistically significant.

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