BCH 361 Lecture Notes - Lecture 6: Pentose, Cytoplasm, Ribose
12 Jan 2017
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Allows cell to produce imp reducing agent used in several pathways, nadph. Nadph used as a reducing agent in processes: fa biosynthesis, nucleotide biosynthesis, detoxification. Provides cells a way to breakdown carbon pentose (5c) sugars obtained from diet. Ribose) that are used to synthesize other biomolecules like. Allows synthesis and breakdown of the less common 4c and 7c sugars. In the process, generate the reducing agent, nadph molecules. 3c, 4c, 5c, 6c, 7c sugars are interconverted from one to another. Excess of 5c = transformed into intermediates of glycolysis. Ultimately: can breakdown 5c sugars and create nadph reducing molecules. Oxidize g6p to release a co2 + 2 nadph. G6p dh catalyzes oxidation of g6p + reduction of nadp+. The oxidative phase begins w/ the dehydrogenation of g6p at c1. An enzyme called g6p dh catalyzes transfer of hydride ion from glucose g6p to nadp+, forming nadph and releasing a. Committed step (irreversible) that is highly exergonic and regulated.
