BCH 361 Lecture Notes - Lecture 10: Heat Shock Protein, Peptide, Pancreatic Ribonuclease
5 Feb 2017
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Document Summary
The protein data bank (pdb) and visualization software. The pdb contains all experimentally determined structures of macromolecules. Each structure given an id number: pdb id. Motifs can be simple or complex: a protein domain is part of a polypeptide chain that is independently stable, has a particular, independent function from the rest of the polypeptide, and often appears in a variety of proteins. Domains can be comprised of a single motif or several simple motifs. Since each type of domain has a particular function, one can mix and match domains to couple functions. It is mathematically impossible for protein folding to occur by randomly trying every conformation until the lo(cid:449)est energ(cid:455) one is found (cid:894)le(cid:448)inthal"s parado(cid:454)(cid:895) Search for the minimum is not random because the direction toward the native structure is thermodynamically most favorable. Energy landscape of protein folding -collapsed structures give rise to molten globules partially formed domains and motifs.
