BCH 361 Lecture 1: Glucose Metabolism

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Glucose metabolism: transform e in chemical bonds of glucose into chemical bonds of atp. Atp used by cells; creating electrochemical gradient using membrane pumps, contracting muscle. Glycolysis: glucose in cytoplasm broken down to 2 pyruvate and net 2 atp molecules. Under aerobic conditions, pyruvate move to mitochondria --> pyruvate decarboxylation, tca cycle, etc (inner membrane) - uses o2 transforms pyruvate to co2 and atp = aerobic cellular respiration. High atp = gluconeogenesis; don"t want to break down glucose. When atp high = pyruvate and lactate transformed back into glucose via gluconeogenesis --> glycogen. Stage 1 of glycolysis (steps 1, 2, 3) Stage 1 traps glucose in cell and destabilizes its structure (=increase overall e = more reactive). Stage 3 oxidize the 2 components to harvest e of the 2 molecules to form atp, pyruvate and nadh molecules. In stage 1, glucose is transformed into fructose 1,6-bisphosphate (f1,6bp) Step 1: hexokinase phosphorylates glucose c6, creating glucose 6-phosphate (g6p)

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