BLG 151 Lecture 8: Chapter 9 notes
20 Nov 2016
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Microbiology (note: only selected sections and examples are covered: sections 9. 1, 9. 2, 9. 3, 9. 4, drug resistance from 9. 8) 9. 1 antimicrobial chemotherapy evolved from antisepsis efforts: propose natural sources of new antimicrobial agents. Naturally produced (bacteria + fungi); synthetic, semisynthetic. Destroy pathogenic microbes or inhibit their growth within host. Microbial products or their derivatives that kill susceptible microbes or inhibit their growth. Penicillin the first true antibiotic, a natural microbial product. First discovered by ernest duchesne (1896), but discovery lost. Did not think could be developed further. Purification and effectiveness demonstrated by florey, chain, and heatley (1939) Fleming, florey, and chain received nobel prize in 1945 for discovery and production of penicillin. 9. 2 antimicrobial drugs need to be selectively toxic over a range of effectiveness: explain the difference between a narrow and broad spectrum drug, correlate drug action with cidal and static effects.
