BLG 307 Lecture Notes - Lincoln Near-Earth Asteroid Research, Hapten, Innate Immune System
Document Summary
Innate genetically hardwired germline evolution stereotypic response primary defense. Adaptive immunity plastic involves shuffling dna somatic varied delayed but efficient. Innate immunity cannot protect against bacterial evasion mechanisms (capsulation) innate only recognizes features common (lps) to certain pathogens. B cells differentiate and cab secrete antibodies secreted antigen receptor = antibody membrane bound are involved in b cell differentiation to plasma cells (t cells also help mediate differentiation) secreted antibodies binding) pathogen) neutralization (toxins/viruses) Complement assistance (leads to pore formation in. T cells recognize antigens presented of surface of infected cells. Clonal selection theory: b cells generate antibody diversity at random, an antigen encounter leads to proliferation and differentiation, progeny have identical antigen recognition, self-responsive antibodies are deleted (tolerance) Lag period between encounter and primary response proliferation takes time memory cells are produced which mediate secondary response more cells that recognize antigen to start with heightened response.
