Class Notes (835,722)
Canada (509,348)
Biology (529)
BLG 307 (38)
Clare Chua (38)
Lecture

cd4 t cells

3 Pages
57 Views
Unlock Document

Department
Biology
Course
BLG 307
Professor
Clare Chua
Semester
Fall

Description
CD4 T-HELPER CELL EFFECTOR FUNCTIONS antigen recognition does not occur at site of entry, but usually in lymph nodes/spleen activated T cells then migrate to target tissues T-CELL PROLIFERATION IL2R – complex of αβγ that associate non-covalently essential for immune function, as its chains are involved in MANY ILR’s IL2 is not absolutely necessary b/c other cytokines can replace function ag:MHC complex binding to TCR triggers IL2R assembly/synthesis ensures that IL2 only activates clonal expansion of ag-specific cells ag:MHC complex binding to TCR can also stimulate IL2 SYNTHESIS some cells can make IL2  autocrine/endogenous can be used can’t make IL2  paracrine/exogenous IL2 necessary other IL’s IL4 – growth factor, similar to IL2 IL7 – growth factor for immature T cells (CD4-, CD8-) in thymus produced by thymus stromal cells ILR’s are coupled to tyrosine kinases Jaks phos. STATs (TF’s) CD4 CELL SUBCLASSES TH1 – synthesize IL2/3, TNFα, γ-INTERFERON activates macrophages and enhances their ability to kill ingested microbes (bacteria, fungi, protozoa) 1) γ-inteferon is released in response to macrophage MHC II antigen presentation 2) CD40 (macrophage) binds CD40L(T cell) and/or TNF (T cell) interacts with TNF-R (macrophage) these combined enhance macrophage lysosome-phagosome fusion enhanced macro
More Less

Related notes for BLG 307

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit