BLG 307 Lecture Notes - Cd19, Cowpox, Monocyte
Document Summary
Proteins necessary for humoral and cellular immjunity in a highly regulated cascade of proteolytic events. Activated directly by exposure to foreign cell surfaces. Split products mediate cell migration, activation/adhesion- interact with cr on other cells (leuk/plat/endo/sm/epi) Terminal proteins (c5b-c9) = pore forming structure that can activate or lyse cells. Complement initiates: attracting/activating granulocytes and macs, opsonizing bacteria/cells to target for phag, pore formation in c ell membranes rupture, activation of antigen-specific b and t cells. Complement actiavation (all converge in the activation of c3: classical pathway, c1 binds fc portion of antibody via q domain (c1q) C1 is a multiprotein complex: c1q has six ubunits with collagen like tails and globular head. Ab can be with antigen or on cell surface. Must bind multiple antibodies fc"s for protease activity. (igm bound to antigen for steric change 2 igg"s aggregagte by binding antigenic surace)
