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Biology (528)
BLG 307 (38)
Clare Chua (38)
Lecture

dendritic cells

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Department
Biology
Course
BLG 307
Professor
Clare Chua
Semester
Fall

Description
Outline of Lecture 12 Dendritic Cells (and other Antigen Presenting Cells) I. Overview - Professional APCs are DC, macrophages, B cells; express MHC II - DCs are the most efficient APC for primary immune response II. DC Life Cycle 0) DC progenitors migrate from bone marrow to peripheral tissues 1) Immature DC’s continually sample environment until Ag is encountered - Active MHC II synthesis, expressed intracellularly - Active macropinocytosis to sample environment (inefficient) - Sampling aided by adsorptive endocytosis using PRRs - Regulated: ↑by GM-CSF, ↓by LPS, TNF, IL-1 - Maturation stops Ag sampling, MHC II expressed on surface and gives snapshot of Ag’s that were presen
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