BLG 307 Lecture Notes - Mecha, Dendritic Cell, Tyrosinase
Document Summary
Coley"s toxin activation of t cells to fight tumors. Rag2 knockout mice no b/t cells totally immunodeficint more cancer. Rag/stat double knockouts are even more susceptible to cancer (stat is involved in g-ifn signaling activation pathway) Tumors generated in immunodeficient mice that are transplanted to immunocompetent mice can be cleared. Humans cancer/viral infection can activate innate immune response. Sensor systems are specific for certain self-ligands some evidence that correlates immunosuppressive therapy w/ cancer correlation between t-cells that infiltrate ovarian tumors and survivability. T cells chance the tumor microenvironment be secreting chemokines melanoma patients: t cells are antigen-specific to overexpressed pigment protein there are more memory cells also. Nkg2d lyses infected cells, cellular stress (mica, micb) Nkg2a lyses non-mhci presenting cells (cancerous, virally infected cells) (mhc classes: Ia classical mhc"s recognized by peptide specific tcr"s peptide independent nkr"s. Ib nonclassical mhc"s recognized by nk"s, ctl"s) observed cancer strategy: release soluble mica and bind up nkg2d"s!!
