BLG 311 Lecture Notes - Lecture 13: Golgi Apparatus, Pinocytosis, Lysosome

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Roadmap of the endocytic, biosynthetic and recycling vesicular pathways. If there is a constant flow of membranes only from the er, then the er will shrink because vesicle carriers are continuously breaking off; thus, a retrieval pathway is necessary. Organelle identity markers: proteins specific to each organelle determine the identity of that organelle: what to import (fuse) and what to export (bud off) Its big skill is that it can self-assemble; it loves fitting in of its kind. with others. Adaptor protein complexes (ap) are intermediates between cargo molecules and clathrin: during clathrin-mediated endocytosis, cargo is sorted and enriched in budding vesicles, cargo may be membrane proteins or soluble cargo. If soluble cargo, this is first bound to transmembrane proteins called receptors: clathrin ap (adaptor protein complex) membrane cargo (for the vesicle) In addition to this, clathrin-mediated receptor endocytosis involves ~50 different proteins (not just as shown)

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