BLG 699 Lecture Notes - Lecture 8: Genotoxicity, Therapeutic Index, Median Lethal Dose
Document Summary
Blg 699 wk 8&9 preclinical & animal testing. Specific strong effects on a specific targeted biological pathway and minimal effects on all other pathways, to reduce side effect. In reality, no drugs are perfectly effective and absolutely safe. Depends on the chemical and structural specificity of the drug-target interaction. Pd - potency & effectiveness effect at a low dose. Potency: this is the dose required to generate an effect. Effectiveness: this is the intensity of the effect or response. It is a measure of the effect of the drug for the receptor. An effective drug is one that can achieve affects in the vicinity of emax. Therapeutic index (relative desirability) = ld 50 / ed 50. Is the study of the kinetics of absorption, distribution, metabolism, and excretion of drugs. Conducted for the period of time consistent with therapeutic indication. And to the length of the clinical program. Two non-human mammalian species (one rodent and one non-rodent species)
