BMS 451 Lecture Notes - Lecture 20: Cervical Cancer, Immunodeficiency, Critical Role
13 Dec 2016
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Document Summary
Lecture 20- persistent viral infections- herpesvirus, hpv and viral hepatitis chronic and latent infections. While many viruses cause acute infections, several persist for a period beyond the initial period. Chronic infections can occur with a slow release of active virions over the life of a host. Latent infections occur when a virus remains dormant before emerging later in response to some stimulus: virus can express gene that keeps it in latency or no secretion or genes expressed and it hides from immune system. Transforming viruses are those leading to malignancies due to chronic infection herpesvirus. Large, double stranded dna viruses- complex genome gives the virus the ability to interfere with immune response- inhibits apoptosis, and host cells from expressing mhci antigens. Alphaherpes viruses: herpes simplex virus- cold sores, varicella zoster (chicken pox) Gammaherpes viruses: epstein-barr virus- associated with cancer, kaposi"s sar(cid:272)o(cid:373)a-associated herpesvirus (hhv-8) Enveloped virus with a surface glycoprotein receptor.
