BMS 451 Lecture Notes - Lecture 22: Vacuole, Influenza A Virus, Aids
13 Dec 2016
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Document Summary
Most aspects of viral replication are potential targets. Any parts that depend on the host pathways are not acceptable. Viral diversity means that drugs developed for one infection may not work for another virus. Acidification step between penetration to uncoating- if you block it, you can block virus. Among the earliest antivirals developed were interferon and ribavirin. Ifn is a protein that is released in response to viral infection and that prevents infection by. If you can block binding, you can block the virus. If you can interfere with protease, you can interfere maturation of the virus other viruses. Ribavirin is a nucleoside analog that inhibits many rna viruses (it also has toxicity because it interferes with cellular processes) inhibition of virus entry. Maraviroc is a drug that blocks this interaction- competitive inhibitor. Must be able to demonstrate that the cells in the patient are susceptible to treatment- dosage is important virus uncoating.
