BMS 451 Lecture Notes - Lecture 14: Causative, Neisseria Gonorrhoeae, Vacuolization
13 Dec 2016
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Lecture 14- obligate intracellular pathogens- chlamydia, rickettsia, and coxiella chlamydia spp. 2 main species in humans: c. trachomatis sti (affects the eyes, c. pneumoniae respiratory infection, also called walking pneumonia. Auxotrophic for several amino acids and ctp, gtp and ttp (can"t produce those compounds that replicates and fills the infected cell until it ruptures and spills contents it needs to survive, relies on host) chlamydial sti. Risk of pelvic inflammatory disease in asymptomatic/untreated women (70% don"t show symptoms) Inflammation begins at cervix, can ascend into uterus and fallopian tubes trachoma- disease of the eye. Leading cause of infectious blindness- spread by droplets. Begins as mild inflammation on back of eyelid, will spread and will cause thickening of the eyelid. Edge of eyelid folds into the eye and causes eyelashes to scrape eye, can lead to blindness pneumonia. C. psittaci- occupational hazard in poultry farmers, parrot fever biphasic morphology of chlamydia. Goes through 2 forms during the infectious cycle.
