BMS 860 Lecture Notes - Lecture 10: Glioblastoma Multiforme, Aspirin, Papilloma
26 Feb 2017
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Document Summary
Telomere loss leads to chromosome abnormalities in cancer. Translocations (rearrangments of parts between nonhomologous chromosomes) Chromosomal breakage, fusion and bridge formation occur when telomeres have become too short to protect the ends of chromosomal dna. Erosion of telomeres on p arm of chromosome leads to end to end fusion of sister chromatids. This conformation is called dicentric chromosome- 2 telomeres and 1 shared centromere. During mitosis, each sister chromatid is normally pulled to opposite ends by mitotic spindle. Will form anaphase bridges when pulled apart. The sisters will break at weakest point, random. If they undergo another division, the larger fragment can bind with another broken pair and. In the fused sister chromosomes, the spindle tries to do the same continue the bfb cycle. Bfb cycles lead to increase in chromosomal rearrangements and the amplification and deletion of chromosomal segments adjacent to breakpoint. Novel oncogenes, amplified oncogenes, loss of tsgs.
