BLG 307 Lecture Notes - Lymph Node, Opsin, Granzyme B
Document Summary
Recall: tlr transducer signal into macrophage triggering an intracellular signal transduction cascade that activates transcription factors (nfkb) that transactivate the transcription of inflammatory genes. Neutrophils- shortlived phags that kill microbes w/ roi and degradative enzymes. Macrophages-longlived phags that kill and regulate inflammation and remodeling. Attach to bugs via fcr or c3r, fuse lysosomes, produce ros and rni. Eosinophils -attach to parasite via c3r and release granules. Basophils (mast cells)-attach to bugs via ige, release granules, allergic responses (come from pluripotential hematopoietic stem cell (myeloid progenitor) Neutrophils short lived (days) acute inflammation kill bacteria. Macrophages long lived chronic inflammation kill bacteria and regulate inflammation cytokine secretion can present antigens. First cells to arrive at inflammatory site (may be called by resident macrophages) Natural immunity defense mechanism before lymphocyte driven immune response. 2 week differentiation process: mature neutrophils do not divide. 2 granules = complement receptors for chemoattractants and adhesion molecules intracellular stores that are rapidly mobilized during inflammatory response.
