BLG 307 Lecture Notes - Ciclosporin, Opportunistic Infection, Tx Network

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Published on 28 Jan 2013
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ALLORESPONSES/ TRANSPLANTATION IMMUNOLOGY
Transplant rejection is an immune response
- transplants WITHIN inbred strains succeed
- transplants BETWEEN inbred strains fail
second set rejection is faster, more intense (due to immunologic memory)
second set from an unrelated part is akin to a first set (specificity)
memory resides in lymphocytes (and can thus be transferred)
Terminology:
autologous – same person
syngeneic – between genetically identical individuals (inbred strains)
allogeneic – genetically different but same species
xenogeneic – different species
Genes responsible for transplant rejection are at HLA and encode MHC I and II
Laws of transplant rejection
1. transplants within inbred strains succeed
2. transplants between inbred strains fail
3. from inbred parental (aa) to F1 (ab) will succeed; reverse won’t
4. from F2 and all subsequent generations to F1 will succeed
5. parental to F2 GENERALLY fail, but not always
% graft survival = (3/4)n where n=number of histocompatability genes
(approx. 30-50)
ONE-WAY MLR = mixed lymphocyte reaction; in vitro correlate to tissue rejection
mix blood samples from patient A and B (irradiate B no mitosis)
monitor T cell proliferation of patient A in response to B antigens
primary response to ALLOANTIGENS is much more vigorous than primary
responses to generic antigens (ie ovalbumin)
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