BLG 307 Lecture Notes - Cytokine, Wild Type, Cd74

45 views4 pages
28 Jan 2013
Department
Course
Professor
T-CELL ANTIGEN RECOGNITION
B and T cells are morphologically identical
Claman studies –
BOTH T and B cells are necessary for antibody response to antigen
T cells obey CLONAL SELECTION also
T cells don’t secrete antibodies once activated; they just proliferate
sole function of THYMUS is to make T cells
UNIQUE ANTIGEN RECOGNITION MECHANISM
T cells recognize short linear aa stretches (approx. 10 aa’s) no CONF. DET.
only recognize proteins (no CHO’s)
antigens must be PRESENTED on APC (antigen presenting cell)
DENDRITIC cells
Macrophages, to an extent
MHC RESTRICTION – T cells only respond to host APC’s
indicates there must be a genetic link
link is the major histocompatability complex
lots of polymorphism in the MHC between individuals
MHC: (HLA in humans)
encodes cell surface proteins recognized by T cells
3 classes of genes (I, II, III)
class human mouse Comp
I A, B, C genes K,D,L HC, β2
II DP, DQ, DR IA, IE α, β
Class I – expressed everywhere except RBC, neural tiss.
Class II – B Cells, macrophages, dendridic cells
**these genes are highly polymorphic** “balanced polymorphism”
no “wild-type” exists
***a T cell recognizes ONE of the several expressed MHC on an APC***
Unlock document

This preview shows page 1 of the document.
Unlock all 4 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
Monthly
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.