BLG 307 Lecture Notes - Il2Ra, Autoimmunity, Immunoglobulin A
Document Summary
Janeway: immune system responds to antigen + presence of pamp/prr int. no pamp/prr interaction tolerance. Matzinger: danger theory antigens presented during danger lead to immune system response danger = release of necrotic cell proteins (hsp"s) Thymus positive selection: only t cells that can interact with self-mhc"s will mature negative selection: if binding to peptide:mhc complex is too tight deletion. **unlikely that all self antigens are present in thymus during dev. Ignorance t-cells are potentially autoreactive but not enough antigen is present to elicit a response. Clonal deletion high amount of auto-antigen present clonal deletion low amount of auto-antigen present ignorance. T cell anergy tolerance that occurs in presence of antigen, but not costimulation tolerance remains in memory anergic reponse can be reversed by il-2 activation. T regulatory cells subset of cd4+ cd25+ cells inhibit il2 production and. Tr1 cells make il-10 inhibits other cytokine syntheses. Peyer"s patches contain many t-helper cells to promote.
