BMS 870 Lecture Notes - Lecture 17: Posterior Grey Column, Trigeminal Nerve Nuclei, Trigeminal Nerve

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Types and layers of skin: hairy and glabrous + epidermis and dermis. Function of skin: protects, prevents evaporation, provides direct contact. Pacinian corpuscles - largest, best studied, in fat layers of dermis. Ruffini"s endings - slightly smaller than pacinian, found in hairy and glabrous skin. Meissner"s corpuscles - 1/10 size of pacinian, found in ridges of glabrous skin. Merkel"s disks - nerve terminal + non-neural epithelial cells. Free nerve endings - light touch and pain. Meissner"s corpuscles - small receptive fields, adapt quickly = fingers and palms. Pacinian corpuscles - large, adapts qucikly = deep pressure. Vibrations related to music felt by pacinian corpuscules. Selectivity of mechanoreceptive axon depends on structure of its special ending. Pacinian corpuscule has football-shaped capsule w/ 60-70 layers of connective tissue + nerve terminal. Compress capsule = energy to nerve terminal, capsule membrane deformed, mechanosensitive channels open. Current flow through channel generates receptor potential = depolarizes = axon fires ap.

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