ENH 220 Lecture Notes - Lecture 9: Emulsion, Gut Flora, Hepatitis A Vaccine

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Chapter 16- the liver, the biliary system, and pancreas. The liver: largest organ in body, right upper abdominal area, beneath the diaphragm, main functions. Metabolism: carbohydrates, protein, and fat delivered through the portal circulation. Detoxification and excretion: various substances: has a double blood supply. Portal vein: 75% of blood, drains spleen and gi tract, rich in nutrients absorbed from intestines, low in oxygen. Hepatic artery: rest of blood, high in oxygen, low in nutrients. Both blood mix in the liver eventually collecting into right and left hepatic veins that drain into inferior vena cava: portal triad/portal tracts travel together. Bile salts: major constituent of bile; derivatives of cholesterol and amino acids; emulsify fat; act as detergents: bile is secreted continually. During digestion, gallbladder contracts, releasing bile into the duodenum (digestive tract) Bile does not contain digestive enzymes, but acts as a biologic detergent. Mixed necrosis and fatty change: common types of liver injury.

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