OHS 322 Lecture Notes - Lecture 3: Tubular Fluid, Xenobiotic, Chloroform

• School: Ryerson University
• Department: Occupational Health
• Course: OHS 322
• Professor: Eric Liberda

Document Summary

Adme: absorption, distribution, metabolism and excretion = adbe: absoption, distribution, Determinants of toxicity: inherent nature and reactivity of chemical. Concentration and duration in target organ (the site where it produces damage one or several. 3 major exposure routes: inhalation, dermal, ingestion (also injection) Concentration at site of action depends on adme once chemical is in body. Toxicokinetics: toxicokinetics = what the body is doing to the chemical, determining rates of which absorption, distribution and elimination is happening, toxicodynamics = what the chemical is doing to the body. Inhalation lungs: highly vascularized, larger surface area. Dermal skin: not highly permeable to most chemicals, but lipid soluble chemicals well absorbed. Ingestion gastrointestinal: larger surface area, variable ph. Injection- by passing adme< you can get the full load in your bloodstream, bypassing the absoption. Absorption (ease of getting across membrane) is dependent on: Hydrophobic: diffuse across lipid domain of membrane. (lipophilic, likes fat)