OHS 322 Lecture Notes - Lecture 4: Toxicokinetics, Intramuscular Injection, Biomonitoring

• School: Ryerson University
• Department: Occupational Health
• Course: OHS 322
• Professor: Eric Liberda

Document Summary

Toxicokinetics: toxicokinetics = what the body is doing to the chemical, determining rates of absorption, distribution and elimination, toxicodynamics = what the chemical is doing to the body. How does the body respond to the chemical before. What happens now, when the chemical reaches your brain how it causes a toxic effect. Toxicokinetics = mathematical description of the time course of the disposition of a chemical. Classical toxicokinetics: the disposition of a chemical is described by its concentration in the plasma with respect to time. Can involve complex mathematical modeling of the metabolism of a chemical. Can predict the body burden of a chemical, duration of the chemical in the body after exposure has stopped, calculate a half life, and other information in order to assess the risk involved in exposure. Classical - body as one or two compartments. Toxicokinetics: what is constant is the proportion of chemical eliminated = proportionality constant.