PAT 20A/B Lecture Notes - Lecture 2: Endothelium, Antiplatelet Drug, Angiogenesis
12 Nov 2018
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Document Summary
Week 3: inflammation (concept) {chapter 18, chapter 17 (pg. 225-227): list the cells involved in the inflammatory response and state their function. Single layer of cells that line bvs to separate intracellular & extracellular spaces. Produce antiplatelet & antithrombotic agents stop platelets from coagulating. Maintain bv patency like vasodilators & vasoconstrictors to control blood flow. Provide selective permeability barrier to exogenous (microbial) and endogenous inflammatory stimuli. Regulation & modulation of immune responses through synthesis & release of inflammatory mediators. Regulate immune cell reproduction by secreting hematopoietic colony-stimulating factors. Involved in repair process accompanying inflammation by producing growth factors to stimulate angiogenesis (formation of new bvs) & extracellular matrix synthesis. Activated platelets release potent inflammatory mediators that increase vascular permeability & alter the chemotactic, adhesive & proteolytic properties of endothelial cells. Activated platelet releases 300 proteins many are inflammatory mediators. First leukocyte to arrive to site of inflammation (within 90 mins of injury)
