PAT 20A/B Lecture Notes - Lecture 2: Vascular Permeability, Cell Adhesion, Mast Cell
8 Oct 2014
School
Department
Course
Professor
Document Summary
It"s the response of vascularized tissues to harmful stimuli and the body"s attempt to restore homeostasis. Its purpose is to neutralize/destroy foreign material, restrict tissue damage, alert individual to impending threat of tissue injury and prepare injured area for healing. Eosinophils, basophils, mast cells: mast cells are important because they store histamine and serotonin which release these mediators in response to stimulus. It"s early/immediate reaction to injury and occurs before immune response kicks in. Redness, swelling from increased vascular permeability (leaky cell, endothelial cell contracting) that fluid shifting, heat from vasodilation, pain and loss of function. Transudate comes out first and then exudate: describe the sequence of vascular changes in acute inflammation (vasodilation, increased permeability) and explain their purpose. Right after the injury, arterioles in the area briefly undergo vasoconstriction (sympathetic nervous system). The platelets will then become denser and stick to the vessel walls, forming a clot, and release pro inflammatory mediators like histamine and serotonin to promote vasodilation.
