PAT 20A/B Lecture Notes - Lecture 2: Adrenal Medulla, Lipopolysaccharide, Opsonin
9 May 2016
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Document Summary
To protect against injury and infection, the body has various defence mechanism. Consist of monocyte and macrophages and their precursor cell. It contains phagocytic cell located in various tissue and organ. Monocytes becomes macrophages once they leave the blood and enter the tissue. The function of macrophages system includes: recognition and phagocytosis of foreign materials such as microorganism, removal of old and damaged cell from circulation, participation in the immune response. Biological response to cell injury by pathogen, irritants, or chronic health condition. Establish a environment suitable for healing and repair. The inflammatory response can be divided into: vascular response, cellular response, formation of exudate, healing process. Platelets adhere to vessels and aggregate to seal the injured area, forming a fibrin-platelets clot and release proinflammatory mediators such as histamine, which cause vasodilation. Initially composed of serous fluid, this inflammatory exudate later contains plasma protein, primarily albumin exert oncotic pressure draws fluid from the blood vessels edematous.
