PAT 20A/B Lecture Notes - Lecture 11: Optic Disc, Hyponatremia, Diuretic
2 Nov 2017
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Traumatic brain injury: discuss the relationship between icp, bp, cpp and cerebral blood flow. If 1 component increases then the other 2 must compensate by displacement for pressure to remain constant = monroe-kellie hypothesis: the total intracranial volume will not change. If any of the 3 components increases without a corresponding decrease in another component rapid increase in icp from the normal range (0-15 mmhg) Increased icp: > 20 mm hg for > 5 minutes results in impaired cerebral perfusion. Factors influencing icp: blood pressure, cardiac function. Factors influencing cerebral blood flow: carbon dioxide ( co2=dilate= icp, oxygen ( o2=dilate= icp, hydrogen ion concentration ( acid, cbf = mls of blood passing through 100mg of brain/min, within the minute 100 g of brain tissue receives approx. 750 mls blood: unlike other organs, the brain lacks the ability to store oxygen or glucose, and therefore the maintenance of adequate blood flow to the brain is critical for neuronal functioning and survival.
