PLN 203 Lecture Notes - Lecture 9: Cytotoxic T Cell, Kupffer Cell, Memory T Cell
23 Mar 2017
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Document Summary
Adaptive (specific) defenses: specific resistance (immunity, responds to specific antigens, with coordinated action of t and b cells. T cells provide cell-mediated immunity & defend against abnormal cells/pathogens inside cells: b cells provide antibody-mediated immunity & defend against antigens/pathogens in body fluids. Two main divisions: cell-mediated immunity (t cells, antibody-mediated immunity (b cells) T cells ignore normal peptides: pro fragments are derived from extracellular proteins, found in lymphocytes, antigenic fragments from antigenic processing of pathogens, bind to class ii proteins. Inserted in plasma membrane to stimulate t cells: antigen-presenting cells (apcs, responsible for activating t cells against foreign cells and proteins. Free and fixed macrophages (in connective tissue: kupffer cells (of the liver, microglia (cns) Langerhans cells in the skin: dendritic cells in lymph nodes and spleen. Inactive t cell receptor: recognize class i or class ii mhc proteins and specific antigens, binding occurs when mhc protein matches antigen.
