PLN 203 Lecture 10: PLN203 – Immune System – Part III
23 Mar 2017
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Document Summary
Five classes of antibodies: aka immunoglobulin"s (igs) Found in body fluids: determined by constant segments (therefore have no effect on antibody specificity) Igg is the largest and most diverse class of antibodies (80%) Ige attaches as an individual molecule to the exposed surfaces of basophils and mast cells: cell is stimulated to release histamine and other chemicals that accelerate inflammation in. Ige is also important in the allergic response. Igd is an individual molecule on the surfaces of b cells, where it can bind antigens in the extracellular fluid: binding can play a role in the sensitization of the b cells involved. First class of antibody secreted after an antigen is encountered: concentrated declines as igg production accelerates, plasma cells secrete individual igm molecules, but it polymerizes and circulates as a five-antibody starburst. The anti-a and anti-b antibodies responsible for the agglutination of incompatible blood types are. Igm antibodies may also attack bac that are insensitive to igm.
