PSY 214 Lecture Notes - Lecture 9: Radial Arm Maze, Cannabinoid Receptor Type 2, Cannabinoid
2 May 2016
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Document Summary
A cannabinoid receptor in the cns was identified in 1988. Receptors occur in many brain areas including the basal ganglia, cerebellum, hippocampus and cerebral cortex. Cb1 is the receptor found in the cns. Cb2 occurs in the immune system and other tissues such as bone, adipose (fat) cells, and the gi tract. Cannabinoid receptors are metabotropic; they work via g proteins to inhibit camp formation, inhibit voltage-sensitive ca2+ channels, and open k+ channels. Cb1 receptors are located on axon terminals. By activating these presynaptic receptors, cannabinoids can inhibit the release of many neurotransmitters (such as. Cb1 receptors also play an important role in the reward system. Marijuana potency (in terms of thc content) varies widely, depending on the genetic strain of the plant and growing conditions. Potency can be increased by preventing pollination and seed production by the female plants.
