BIOL 2321 Lecture 34: 34 Experiments, Enzymes
10 Jan 2016
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Unit 3 _ experiments, enzymes, & important questions. Study online at quizlet. com/_1tox6e: adar: adenosine deaminase acting on rna. Converts adenosine into inosine by deamination: amplification in rnai: some sirna unwind without being associated with risc. The antisense strand can bind to its complementary region of the corresponding mrna, serving as a primer for a rdrp which will generate new dsrna of the target gene. Rdrp generated dsrna is substrate for dicer, and more sirna is made. 5"-cap on mrna recognized, then ribosome scans mrna for first aug after cap. Start codon (aug) is located near the 5 -end of the mrna. 16s rrna of ssu recognizes specific sequence upstream of aug start codons. Recognition of the start codons is facilitated by the presence of a ribosome recognition motif (shine-dalgarno, or s-d, sequence). In bacteria, translation usually begins before transcription is completed: the two processes are said to be coupled.
