BIOL 2321 Lecture Notes - Lecture 33: Glutamine, Guide Rna, Exon
10 Jan 2016
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Study online at quizlet. com/_1swnep: adar: adenosine deaminase acting on rna, amplification: some sirna unwind without being associated with risc. The antisense strand can bind to its complementary region of the corresponding mrna, serving as a primer for a which will generate new dsrna of the target gene. Rdrp generated dsrna is substrate for dicer, and more sirna is made. In plants, the sense sirna can be copied by an rdrp that does not require priming, resulting in new sirna. Sirna can go from cell to cell, and so silencing can propagate to other tissues: basic rnai pathway: dicer binds dsrna and cleaves into ~22 nucleotide fragments -> sirnas (small interfering rna). Risc (rna induced silencing complex) binds one sirna. Activated risc binds a target mrna and degrades it: editosome: the newly formed double-stranded region is enveloped by an editosome, a large multi-protein complex that catalyzes the editing.
