BISC 100 Lecture Notes - Lecture 14: Thomas Hunt Morgan, Mendelian Inheritance, Meiosis

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yellowcheetah486

5 Sep 2018

School

Simon Fraser University

Department

Department of Humanities Biological Sciences

Course

BISC 100

Professor

Onkar Bains

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Document Summary

Chromosomes and genes are both present in pairs in diploid cells. During meiosis, homologous chromosomes separate (anaphase i)and allele segregate (ana ii) Fertilization restores the paired condition for both chromosomes and genes (generate a diploid zygote from haploid gametes) Associate a special gene with a special chromosome. An insightful choice take fruit y that eats fungi on fruit. 6. red can be on both male & female. Only homozygous female will have this trait. Male express the sex-linked trait due to only 1 x: males are more likely to inherit sex-linked disorders compared to females, human sex-linked disorders, duchenne muscular dystrophy . Due to absense of an x-linked gene for a muscle protein. Absence of 1+clotting factors (normal have 13); prolonged bleeding bcs a rm clot forms slowly; can be treated with intravenous injections of the missing protein: hypertrichosis . Excessive or animal-like hair on body and face.

Related Questions

1. The eye color of wild-type Drosophila flies is red. Differentmutations in a single or in multiple genes lead to flies with whiteeyes. Mutations in the w gene on the X chromosome lead to whiteeyes instead of the normal red. You have isolated both a white-eyedmutation (designated W-1) that gives a dominant phenotype, and awhite-eyed mutation (designated w-2) that gives a recessivephenotype.

(a) A white-eyed male from the W-1 line is crossed to awild-type female. What color eyes will the female progeny from thiscross have?

(b) What color eyes will the male progeny from the cross in part(a) have?

(c) One of the female progeny from the cross in part (a) ismated to a white-eyed male from the w- 2 line. What fraction of thewhite-eyed progeny from this cross will be female?

2. The body color of Drosophila adult flies is regulated bymultiple genes, including the autosomal ebony gene. Ebony body (e)is recessive to the wild type (yellowish) body (e+). A second gene,which is X-linked, controls bristle shape. Normal bristle shape(f+) is dominant to the mutant forked bristles (f). A female withforked bristles that is heterozygous for the body color gene ismated with an ebony body male (his bristles are normal).

(a) What are the genotypes of the parents?

(b) Using a Punnett square, determine the expected proportionsof each possible progeny phenotype. Since there is a sex-linkedgene here, be sure to include consider sex as part of thephenotype.

3. Describe in your own words what a balancer chromosome is andwhy it is important in fly genetics (you will have to do someresearch for this one!)

mauvepug893

___1. Nationally, the most common cause of Down Syndrome is
a. nondisjunction of Chromosome 21 during meiosis
b. translocation of Chromosome 21 onto another chromosome
c. inversion of a large section of Chromosome 21
d. deletion of the Down Syndrome gene
___2. In humans, sex is determined by
a. The presence or absence of the Y chromosome
b. The ratio of X chromosomes to sets of autosomes
c. The temperature during fetal development
d. Which parent is stronger at the time of conception
___3. A translocation is
a. a chromosomal abnormality in which a piece of one chromosome breaks off and attaches to a different chromosome
b. an abnormality in which the chromosomes are translocated out of the nucleus
c. a condition in which the chromosome has broken in two places and come back together with the middle segment backward
d. an abnormality in which there is an extra copy of one chromosome
___ 4. In snapdragons, a red-flowered plant crossed with a white-flowered plant produces all pink-flowered offspring. But crossing two pink-flowered plants produces red, pink, and white in a 1:2:1 ratio. This is a good example of
a. Incomplete dominance
b. Dominance of the red allele over the white allele
c. Lethal effects of the pink allele
d. Sex-linkage of the flower-color alleles
___ 5. If a person with type AB blood marries a person with Type O blood, what blood types are possible in their children? (Assume this trait is a single-gene trait, not complicated by interaction with other genes).
a. A, B, AB, or O
b. A or B only
c. AB or O only
d. AB only 2
___6. In what phase of meiosis are haploid nuclei first formed? a. Anaphase I b. Metaphase II c. Telophase II d. Metaphase I e. Telophase I
___7. What is the phenotype of a heterozygous tall pea plant? a. tall b. Tt c. TT d. tt e. dominant
___ 8. If genes A and B are far apart on a chromosome, and A and C are close together, which of the following observations is expected?
a. Crossing over will occur more often between A and C than between A and B
b. Crossing over will occur at equal frequencies between A and C, and between A and B
c. Crossing over will occur more often between A and B than between A and C
___9. Sometimes an organismâs genotype for one gene masks the effect of a different gene. This phenomenon is called
a. Dominance
b. Incomplete dominance
c. Co-dominance
d. Epistasis
e. Variable expressivity
___10. The dominant allele of a gene is
a. The one that is expressed most often in a population
b. The one that is expressed most often in any particular cross
c. The one that is expressed in an individual that has two different alleles
d. The one that is most healthy to have, that gives the greatest fitness
___11. In human cells, DNA replication occurs
a. In S phase of interphase
b. In G1 phase of interphase
c. In G2 phase of interphase
d. In prophase of mitosis
e. Whenever the cell needs to read the DNA to make proteins
___ 12. A process in which recipient cells take up genes from DNA molecules floating free in the surrounding medium is called
a. conjugation
b. specialized transduction
c. generalized transduction
d. transformation 3
___ 13. Most calico cats are female. However, a few rare males are observed. What is the genotype of a male calico cat?
a. X BX 0
b. X OY
c. X BY
d. X BYY
e. X BX OY
___ 14. A type of red-green color-blindness is a sex-linked (X-linked) recessive trait in humans. Can a woman have this type of color-blindness?
a. Yes, a woman could be color-blind if her mother and father were both heterozygous.
b. Yes, a woman could be color-blind but only if she has an abnormal number of sex chromosomes.
c. No, women can't show sex-linked traits because they lack a Y chromosome.
d. No, women can't show sex-linked traits because they have two X chromosomes.
e. Yes, a woman could be color-blind if her father was color-blind and her mother was a carrier (heterozygous).

Please show detailed work. Thanks in advance.

16. Syntenic genes can assort independently when

A) they are very close together on a chromosome.

B) they are located on different chromosomes.

C) crossing over occurs rarely between the genes.

D) they are far apart on a chromosome and crossing over occurs frequently between the genes.

E) they are far apart on a chromosome and crossing over occurs very rarely between the genes.

17. The alleles of linked genes tend to

A) segregate together more often than expected by random assortment

B) assort independently.

C) be mutated more often than unlinked genes.

D) experience a higher rate of crossing over.

E) assort independently and show a higher rate of crossing over.

18. If you know that the frequency of recombination between genes X and Y is 34% and between X and Z is 25%, can you predict the order of the three genes?

A) Yes; the order is X-Z-Y.

B) Yes; the order is X-Y-Z.

C) Yes; the order is Z-X-Y.

D) No; based on this data alone, the order could be Z-Y-X or X-Y-Z.

E) No; based on this data alone, the order could be X-Z-Y or Z-X-Y.

Question 19 - 20. You have performed the following dihybrid cross in Drosophila using the black body color (b) and vestigial wing (vg) mutations. The b+ (grey body) and vg+ (normal wing) are dominant wild type alleles. These genes are autosomal.

Female â b+ vg+/b vg Ã male â b vg/b vg

Progeny:

Phenotype # of Progeny

Grey body normal wing 965

Black body vestigial wing 944

Grey body vestigial wing 208

Black body normal wing 195

19. Assuming linkage between black and vestigial, the estimated recombination frequency would be:

0.17

0.09

0.82

1.00

0.50

20. What key test could you use to determine whether the observed offspring frequencies deviate from those expected by chance alone?

A) Pascal's triangle

B) The product rule

C) The Chi-square (Ï²) test

D) The law of random assortment

E) The sum rule

21. In a genome wide association study (GWAS) designed to map the gene(s) that control height you divide subjects into a group of 1000 who are all more than seven feet tall and a control group of 1000 people of average height. You find the following associations between two genetic markers and the height trait:

		Tall group	Control group
Marker 1	Allele A	20%	50%
	Allele T	80%	50%

Marker 2	Allele G	15%	15%
	Allele C	85%	85%

What is your best guess for which marker is more closely linked to a gene that influences height?

A) Marker 1

B) Marker 2

22. Two pure breeding parents produce red and white flowers. They are crossed and the F1 produces pink flowers. When the F1 are selfed to produce the F2, nine distinct classes of pigmentation are present among F2 individuals. What is your best guess of the minimum number of genes that underlie flower pigmentation in this species?

A. 2

B. 3

C. 4

D. 5

E. 6

23. In a quantitative genetic experiment you identify two genes that confer bands of color on the back of a fly. At each gene, a dominant allele causes one band of color. If flies that are heterozygous at both loci are crossed, what ratio of offspring do you expect in each phenotype (i.e., number of color bands) class? (answer options are given from lowest to highest band number)

A) 1:1:1:1:1

B) 1:2:2:2:1

C) 1:4:6:4:1

D) 4:4:4:4:4

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BISC 100 Lecture Notes - Lecture 14: Thomas Hunt Morgan, Mendelian Inheritance, Meiosis

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