BISC 300 Lecture Notes - Lecture 12: Linkage Disequilibrium, Haplotype, Allele Frequency

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List the fitness costs and benefits of sexual reproduction. Explain why recombination is important for generating genetic variation. Define linkage disequilibrium and relate the coefficient of ld to recombination. Describe why ld is important for our understand of selection. Discuss the two hypotheses for the short-term benefit of sex. Costly: lots of courtship, lots of competition. Dangerous: risk of predation during courtship, risk of disease. Previously, under hwe we thought about tracking allele frequencies with one locus. Now, we expand to 2 loci, and so can also think about tracking chromosome (haplotype) frequencies. Why does this matter: does selection at one locus affect our ability to make predictions (under hwe) about the 2nd locus, depends are the loci in linkage equilibrium or disequilibrium. The independent assortment of alleles at unlinked loci. Here, locus a/a and b/b are independent of each other, so all haplotypes are possible in the gametes.

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