BPK 205 Lecture Notes - Lecture 23: Blood Film, Haematopoiesis, White Blood Cell
30 Nov 2017
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Document Summary
Blood = ~7% of total body weight: about 5l in a 70kg male and 4l in a 58kg female. Connective tissue: watery extracellular matrix (plasma) makes up ~1/4 of the body"s ecf, plasma made of -> water, ions, organic molecules (ex. Blood components can be separated by centrifugation: 58% plasma volume, <1% white cells, 42% packed red cell volume, buffy layer -> platelets and white cells between plasma and. In adults, hematopoiesis occurs in the (red) bone marrow of the pelvis, spine, ribs, cranium, and proximal ends (i. e. closest to torso) of long bones. Within active bone marrow -> ~25% of the developing cells will become. Ratio is due to difference of lifespan and turnover: rbc ~120 days, wbcs ~6-12 hours, megakaryocyte is cleaved into little bits to create platelets. Cytokines control the production and development of blood cells: cytokines = proteins released from 1 cell that affects the activity of another.
