BPK 305 Lecture Notes - Lecture 21: Coronary Artery Disease, Acidosis, Pericardium

• School: Simon Fraser University
• Department: Biomedical Physio & Kines
• Course: BPK 305
• Professor: Damon Poburko

Document Summary

Myocardial ischemia = lack of blood supply. There are varying levels of ischemia: local vs. global, partial vs. complete, location, the vessels affected/blocked (ex. Area at risk : transmural location, location and extent of the block largely determines the extent of cardiac damage. The subendocardium is particularly sensitive to ischemia (i. e. partial ischemia: epicardium is better able to handle ischemia. Transmural ischemia requires decreased blood supply across the entire wall (ex. thrombus) Supply and demand mismatch: anoxia/hypoxia, decreased free fatty acids and glucose, decreased delivery due to lack of blood flow, build up of waste products co2, lactate, k+, h, decreased removal due to lack of blood flow. Increased h+ = increased proton concentration: so in the cytoplasm there is. Increased lactate, increased h+ (acidosis), and decreased o2. 2: reactive oxygen and nitrogen species (ros/rns) generated by. Nadph oxidases and mitochondria cause injury: ex.