BPK 305 Lecture Notes - Lecture 32: Ventral Respiratory Group, Dorsal Respiratory Group, Solitary Tract

• School: Simon Fraser University
• Department: Biomedical Physio & Kines
• Course: BPK 305
• Professor: Damon Poburko

Document Summary

Lecture 32 and 33 control of ventilation. 2: 3) pneumotaxic enter, shortens/inhibits inspiration, eupnea = normal breathing, apneuses = tonic contraction of the respiratory muscles -> prolonged inspiration. Inspiration: phrenic nerve output to diaphragm increases over 0. 5 to 2 seconds, expiration, after a brief burst, phrenic nerve is inactive, also a spectrum of firing patterns in different respiratory neurons within the. 3: strong acute ventilatory response, respiratory phart has greater (and faster) effect than metabolic. Phart on phcsf: due to low blood-brain-barrier permeation by hco3, dependence of ventilation on paco2, csf ph modulates sensitivity to pco2, metabolic acidosis increases central co2 sensitivity (ex. diabetic ketoacidosis, metabolic alkalosis decreases central co2 sensitivity. Peripheral chemoreceptors: aortic and carotid sinuses baroreceptors, aortic and carotid bodies, high perfusion (40x > brain/weight, responds to changes in pao2, paco2, ph, only sensor for o2, responsible for about 40% of the ventilatory response to. Co2: glomus cells (neuron-like) sense o2, co2, h+