Class Notes (837,791)
Canada (510,470)
BPK 306 (44)

Arterioles and Control of Resistance Lecture Notes

4 Pages
Unlock Document

Biomedical Physio & Kines
BPK 306
Mike Walsh

IV. ARTERIOLES AND CONTROL OF RESISTANCE A. Local Factors: o Endothelial Cells  EDRF = NO • Endothelium  SM  cGMP produces PKG • PKG = vasodilation o Phosphorylates:  Phospholamban  L-type channels  Ca++ ATPase  NCX  K+ channel o Endothelin  Fxns: • Inhibits NO • Contraction of SM • Hypertrophy of SM • IP3  Arteriosclerosis o Endothelial-derived Hyperpolarization Factor  K+ channel in SM  L-type Ca++ channel o Myogenic Response Autoregulation (fig. 18-22)  Stretch sensitive nonspecific cation channels of SM?? o Metabolites  Adenosine  K+  PCO2  Decreased PO2  RESULT = decr [Ca++]i  Active hyperemia, ischemia B. Neural Factors: o SNS  Alpha-adrenergic stimulation of phospholipase C  Beta2-adrenergic stimulation = vasodilation  Adrenaline and noradrenaline o PNS  NO production  Smaller influence than SNS C. Endocrine Factors: o Catecholamines  SNS, adrenal gland  Adrenaline, Epinephrine  Noradrenaline, norepinephrine o Angiotensin II  SNS/low kidney pressure/low Na  renin  converts angiotensinogen  angiontensin I  ACE  angiotensin II  Vasoconstriction  raise BP V. CAPILLARIES A. Anatomy: a. Diameter = 5-10 um b. 10 billion in a body c. Density: brain > striated muscle > liver and bone marrow d. Between 10 and 100 caps per
More Less

Related notes for BPK 306

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.