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Lecture

BPK 306 Lecture Notes - Phospholamban, Sodium-Calcium Exchanger, Adrenal Gland

by OneClass17242 , Fall 2009
4 Pages
71 Views
Fall 2009

Department
Biomedical Physio & Kines
Course Code
BPK 306
Professor
Mike Walsh

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IV. ARTERIOLES AND CONTROL OF RESISTANCE
A. Local Factors:
oEndothelial Cells
EDRF = NO
Endothelium SM cGMP produces PKG
PKG = vasodilation
oPhosphorylates:
Phospholamban
L-type channels
Ca++ ATPase
NCX
K+ channel
oEndothelin
Fxns:
Inhibits NO
Contraction of SM
Hypertrophy of SM
IP3
Arteriosclerosis
oEndothelial-derived Hyperpolarization Factor
K+ channel in SM
L-type Ca++ channel
oMyogenic Response Autoregulation (fig. 18-22)
Stretch sensitive nonspecific cation channels of SM??
oMetabolites
Adenosine
K+
PCO2
Decreased PO2
RESULT = decr [Ca++]i
Active hyperemia, ischemia

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Description
IV. ARTERIOLES AND CONTROL OF RESISTANCE A. Local Factors: o Endothelial Cells  EDRF = NO • Endothelium  SM  cGMP produces PKG • PKG = vasodilation o Phosphorylates:  Phospholamban  L-type channels  Ca++ ATPase  NCX  K+ channel o Endothelin  Fxns: • Inhibits NO • Contraction of SM • Hypertrophy of SM • IP3  Arteriosclerosis o Endothelial-derived Hyperpolarization Factor  K+ channel in SM  L-type Ca++ channel o Myogenic Response Autoregulation (fig. 18-22)  Stretch sensitive nonspecific cation channels of SM?? o Metabolites  Adenosine  K+  PCO2  Decreased PO2  RESULT = decr [Ca++]i  Active hyperemia, ischemia B. Neural Factors: o SNS  Alpha-adrenergic stimulation of phospholipase C  Beta2-adrenergic stimulation = vasodilation  Adrenaline and noradrenaline o PNS  NO production  Smaller influence than SNS C. Endocrine Factors: o Catecholamines  SNS, adrenal gland  Adrenaline, Epinephrine  Noradrenaline, norepinephrine o Angiotensin II  SNS/low kidney pressure/low Na  renin  converts angiotensinogen  angiontensin I  ACE  angiotensin II  Vasoconstriction  raise BP V. CAPILLARIES A. Anatomy: a. Diameter = 5-10 um b. 10 billion in a body c. Density: brain > striated muscle > liver and bone marrow d. Between 10 and 100 caps per
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