BISC 313 Lecture Notes - Lecture 21: Cytochrome P450, Cytochrome C, Toxicokinetics
10 Apr 2019
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2 purposes: facilitate excretion, prepare chemicals for phase 2 rxns. 3 common p1 rxns: oxidation -> more common, reduction, hydrolysis. Majority of oxidation rxns are one enzyme system: called cytochrome p450 mono-oxygenase system, resides in the ser (work with microsomes for research to measure enzyme. Cyp3a4 common in intestines, many pharmaceuticals. Cyp1a1 common in liver, responsible for metabolising env chemicals. Cyto refers to being in the cell. Chrome refers to fact that it contains iron, allows it to change oxidation state and accept. P450 - refers to absorption spectrum, max absorption of 450 electrons during rxns, and pass electrons on to participants in the rxn. Variety of p450 isozymes: some have broad substrate base some have specific chemicals, some found all over the place, all tissues, ubiquitous some are very tissue specific, some are catabolic, break things down, degradation (biotransformation) [hydrophobic -
