HSCI 323 Lecture Notes - Lecture 7: Guanethidine, Beta Blocker, Neurotransmitter

• School: Simon Fraser University
• Department: Health Sciences
• Course: HSCI 323
• Professor: Tim Beischlag

Document Summary

Uses, effects and important infos cardiac arrest anaphylaxis prolong effects of anaesthetics hypotension shock decongestant dilation increase bp sympatholytic (oppose sympathetic) lowers bp. Primarily antagonizes: alpha 1b treatment for benign prostatic hyperplasia cause less hypotension than prazosin. Primarily antagonizes: alpha 1a (smooth muscle, lots in bladder and prostate) aphrodisiac blocks pre and post synaptic a2 receptors increase na release increase bp and tachycardia. See below (beta blockers) selective for b- adregenic receptors (beta blocker) Neurotransmitter release selective for a2 (an agonist) effect is dependent on sympathetic tone. S(cid:373)ooth muscle: peripheral vaso constriction due to sympathetic tone. Clinical uses of beta blockers angina myocardial infarction prevention of recurrent dysrythmias. Chf- more blood coming back to the heart. Hypoglycemia- glucose release controlled by b2 in the liver inhibit na uptake by blocking vmat makes na available for mao antihypertensive drug induced parkinsonism competes with na at net, blocking reuptake= deplete/reduce.