HSCI 323 Lecture Notes - Lecture 11: Sildenafil, Sexual Stimulation, Ergometrine

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Lecture 11: thyroid hormones and drugs, gonadal steroid hormones and drugs. Goal is to shift t4 levels to normal. 4:1 combination of t4 and t3 to mimic physiological conc. Males: stimulate testosterone, leading to spermatogenesis in infertile males. Combination of lh and fsh to mimic lh surge. Lut and fol used to stimulate ovulation and fertility. Ethinyl substitution on one of the carbons in the estrogen making it orally active. Block negative feedback of estrogen, increase gnrh release and therefore lh and fsh. Osteoporosis, reduce risk invasive breast ca in post menopausal women with osteoporosis. Uterine bleeding, endometriosis, metastatic ca of endometrium and breast, amenorrhea, birth control. Less reliable result of alteration of cervical mucus. Absorbed in gi tract but high first pass metabolism. Use: early puberty in males, masculinization and acne in women, decrease libido, treat hypersexuality in male sexual offenders. Use: prostate cancer, must be coadministered with gnrh to block negative feedback by testosterone leading to increased lh.

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