HSCI 100 Lecture Notes - Lecture 16: Ureteric Bud, Underarm Hair, Kidney Development
8 Dec 2016
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Document Summary
Another view for cell fate decisions extrinsic or intrinsic cues. In multicellular organisms, most cells specialize and differentiate. Teratogen: agent that causes abnormal development in utero. Mutagen: agent that causes permanent change in dna sequence. Reciprocal interactions between cells can drive morphogenesis and differentiation. A great deal of development is about where and when. And much of it is due to local (paracrine) signaling. Vasculature supports lung epithelium, which supports vascularization, which supports Neuritogenesis: growth of dendrites and axons can be spurred by secreted signals or growth factors. Series of reciprocal inductions: mesenchymal to epithelial transformation. Embryonic kidney development: mesenchyme induces budding of nephric (wolffian) duct epithelium, ureteric bud promotes mesenchyme differentiation into epithelium, both contribute to kidney formation. These terms are often used interchangeably, however, they are fundamentally different. Aging and senescence describe the phenomenon where changes accumulate over time and lead to a decline in function and the organism reaches its limit for further growth and division.
