HSCI 130 Lecture Notes - Lecture 3: Cortisol Awakening Response, United States Public Health Service, Joseph Goldberger
19 Feb 2017
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HSCI 130 Lecture 4 Notes
Conflict Paradigm
● Who decides if this a real disease, it’s criteria etc
Pellagra
● Lack of Niacin (Vit B3) in diet
● 4 Ds: Dermatitis, Diarrhea, Dementia, Death
○ 17th Century Europe
○ King of Spain: “Mal de la rose”
● Associated with poverty and a diet of corn + little meat
○ Spoiled corn produces toxins??
○ More common in poor people because corn processing had changed and
removed niacin
● Epidemic of Pellagra in US
○ 1902: case reported in Georgia farmer
○ 1907: 88 cases of insane Alabama women in mental asylum
○ 1908: Dr. James Babcock sounds alarm about pellagra
○ 1906-1940: 3 million deaths
● Dr. Joseph Goldberger
○ US public health service doctor
○ 3 week tour of southern institutions
○ Crazy experiments: Rankin Prison Farm Experiment (induced Pellagra), Filthing
Parties, Mississippi Flood of 1927 Red Cross Yeast Supplements, PPF (Pellagra Preventive
Factor)
● Goldberger believed the 3Ms were causing the disease
○ MEAT, MEAL, MOLASSES
○ Cornmeal was the primary food source which had been processed to remove the
niacin, molasses was sugary, meat was fatty.
● Fortification laws were enacted
(EQ) How do health illness and disease change over time?
(EQ) How do you define stress
Hans Selye
○ Hungarian born canadian endocrinologist MD
○ Pioneer of biological effects of stressful stimuli
○ The Stress of Life book
● General Adaptation Syndrome
○ Alarm: body recognizes stressor, fight/flight response
○ Resistance
○ Exhaustion
● Biological Stress Response:
○ Sympathomedullary pathway
○ HPA
● Cortisol
○ Tested in saliva, hair, urine
○ Cortisol awakening response (CAR)
● LEDS life event stress scale
○ Checklist (problems with memory and recall)
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Who decides if this a real disease, it"s criteria etc. Lack of niacin (vit b3) in diet. King of spain: mal de la rose . Associated with poverty and a diet of corn + little meat. More common in poor people because corn processing had changed and removed niacin. 1907: 88 cases of insane alabama women in mental asylum. 1908: dr. james babcock sounds alarm about pellagra. Crazy experiments: rankin prison farm experiment (induced pellagra), filthing. Parties, mississippi flood of 1927 red cross yeast supplements, ppf (pellagra preventive. Goldberger believed the 3ms were causing the disease. Cornmeal was the primary food source which had been processed to remove the niacin, molasses was sugary, meat was fatty. Fortification laws were enacted (eq) how do health illness and disease change over time? (eq) how do you define stress. Pioneer of biological effects of stressful stimuli.
