HSCI 216 Lecture Notes - Lecture 11: Triceps Brachii Muscle, Diabetes Mellitus Type 1, Menarche

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HSCI 216
DAY 11
July 27th, 2017
Adolescence and Puberty
Adolescence and Puberty
Learning Objectives
- To identify the hormones other than sex steroids that are associated with puberty
- To discuss the roles of those hormones during puberty
- To describe the anatomical changes that occur during puberty (separate from maturity of
the sexual organs)
Correlates of HPGA maturation
- Somatotropic Axis
- Adrenarche
- Insulin sensitivity
- Leptin levels
- Body composition
- Skeletal maturation
Somatotropic (GROWTH) axis
- Also regulated by the hypothalamus via release of growth hormone releasing hormone
(GHRH) and somatostatin (SS)
- Act on the pituitary to regulate the release of growth hormone (GH)
- GH stimulates the release of insulin like growth factors (IGFs) from the liver and other
tissues
- GH and IGF-1 stimulate skeletal growth and protein anabolism
- Increased activity in the somatropic axis is a normal part of pubertal development
o Increase in somatropic activity appears to be a consequence of gonadal steroid
production
Estrogen
Testosterone
Both affect GH production by changing amplitude of those
GnRH pulses
- What controls the increase in activity in the somatotropic axis? (answered above)
Hypothalmus GHRH + SS Pituitary GH Liver & other tissues IGF-1
Adrenarche
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