BIO 201 Lecture Notes - Lecture 12: Cytotoxic T Cell, White Blood Cell, Antigen-Presenting Cell

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22 Aug 2018

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Immune system: evolved from need to recognize self from non-self, detect pathogens foreign invaders i. e. viruses, bacteria, parasites, detects self cells gone rogue i. e. cancer. Includes nonspecific defense systems (skin, mucus, cuticle, stomach acid: phagocytic cells (engulf and intracellular digestion) Inflammatory response: antimicrobial peptides (defensins, intereferon, acquired immunity, specific recognition of pathogen by coating, cellular and humoral responses, cellular: cytotoxic cells, humoral: antibody generation. Inflammation: histamine-medicated, enhances access at site of injury defensins. Interferon protein helps neighbouring cells (not infected cells: virus-infected cells secrete interferon, neighbouring cells release substances that inhibit virus reproduction, limits infection spread in the body, same for all virus types. Mammalian immune system anatomy: lymphocytes produced in bone marrow (particularly long bone, lymph nodes. Ileum peyer"s pat(cid:272)hes hold ly(cid:373)pho(cid:272)ytes to atta(cid:272)k (cid:448)iruses that are (cid:374)ot (cid:272)aught earlier i(cid:374) the digestive system: bone marrow b cell maturation, thymus t cell maturation, thymus deteriorates with age.

Related Questions

1. Why is the process of gene rearrangement used in creating antibodies and T-cell receptors (TCRs) so important?

A. This is how our systems produce memory of pervious exposures, a key trait in adaptive immune responses.

B. Without it, we would need a single gene for every antibody and TCR required to mount all the possible responses need ed during our lives

C. interactions with antigens stimulate cells to initiate these processes, building the best and strongest response possible to the antigen

D. this is the same DNA altering process that leads to cancer. Understanding it leads to better treatments for cancer

2. Which of the following is NOT an antimicrobial substance?

A. keratin

B. Lysozyme

C. Defensins

D. Lactoferrins

E. Peroxidases

3. Which of the following is NOT an outcome of fever?

A. Direct destruction of microbes

B. increased release of pro-inflammatory cytokines

C. increased production of lymphocytes

D. increased phagocytic killing by leukocytes

E. increased production of interferons

4. Which of the following pattern recognition receptors is/are anchored in the host cell membrane?

A. Only C-type lectin receptors (CLRs)

B. Only RIG-like receptors (RLRs)

C. TLR and CLRs

D. Only toll-like receptors (TLRs)

E. NLRs and RLRs

F. Only NOD-like receptors (NLRs)

5. Fever allows the body to fight microbial invaders by which of the following mechanisms?

A.Fever plays all of these roles in the body

B. Fever prevents microbes with lower optimum temperatures from growing, giving the immune system time to eliminate those cells

C. Fever increases the inflammatory response, but reduces the production of interferons unless the invader is a dsRNA virus

D. A moderate fever reduces the inflammatory response but stimulates phagocytic activity in neutrophils and eosinophils

E. Fever increases the multiplication of lymphocytes and enhances the release of substances that attract basophils that then engulf the microbial invader

6. According to the clonal selection theory

A. Each B cell is already programmed to produce a specific antibody

B. B cells producing autoantibodies are eliminated in the thymus

C. Self-reactive T cells are killed in the thymus AND B cells producingautoantibodies are eliminated in the thymus

D. Seld-reactive T cells are killed in the thymus

7. Apoptosis

A. is a form of programmed cell death AND is induced in target cells by effector T cytotoxic cells

B. refers to the transformation of B cells into plasma cells

C. is induced in target cells by effector T cytotoxic cell AND results specifically in T cell death

D. results specifically in T cell death AND refers to the transformation of B cells into plama cells

BIO 201 Lecture Notes - Lecture 12: Cytotoxic T Cell, White Blood Cell, Antigen-Presenting Cell

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