NURS 3550H Lecture Notes - Lecture 9: Metformin, Insulin Resistance, Biguanide
28 Dec 2018
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Document Summary
Eventually loss of insulin with prolonged hyperglycemia and hyperinsulinemia causes destruction of beta cells. Often associated with obesity (obesity is link to insulin resistance) Reduce glucose absorption from gi increase incretin activity. Metformin (only member of this family of drugs) Kinetics renal elimination (kidneys are commonly damaged with diabetes nephropathy) Hepatic gluconeogenesis (formation of glucose from aa) Intestinal absorption of glucose (less glucose moving into the blood) sensitizes insulin receptors (reducing insulin resistance) not acting through insulin release** Glucose uptake into skeletal muscle, adipose tissue. Decrease hba1c (measure of how much glucose has been present in the blood over the last. Weight loss (very least weight neutral does not cause weight gain like many medications) Metformin indications: first choice in treatment of type 2 diabetes. Canadian diabetes association clinical practice guidelines pharmacologic management of. Chapter 13; william harper, maureen clement, ronald goldenberg, amir. Hanna, andrea main, ravi retnakaran, diana sherifali,vincent woo, jean-fran ois yale.
