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BIOL 2000 Lecture Notes - Positron, World Federation Of Trade Unions, Peptidyl Transferase

Course Code
BIOL 2000
Joseph Rasmussen

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Chapter 9-4
Key sites of interaction in the ribosome
A site- decoding center
o Aminoacyl
o Binding site for aminoacylated
P site-
o Peptidyl
o tRNA has a peptide attached at this site
E site
o Exit site
o After tRNA has delivered amino acid it comes here
Peptidyl transferase center
o Business end of ribosome where enzymatic activity occurs
o Where peptide bond formation occurs
o Between new amino acid and carboxyl terminus end of the
polypeptide chain
tRNA movement
o A site to P site to E site then leave ribosome
Inititation of translation
1) Binding of the mRNA to the small subunit (SSU)
2) Recognition of a start codon
o Usually AUG
o Utilizes a specialized initiator tRNA
Prokaryotes tRNAfMet
F met= formyl methionine
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