BIOL 3420 Lecture Notes - Gene Product, Conformational Change, Cytoplasm
Document Summary
Clicker: which is not one of the three main classes of hormones, polypeptide, purines, steroids, amines, all of the following are true of steroid hormones except, they are synthesize din the smooth er or mitochondria on demand, they typically rely on intracellular receptors in the cytosol or nucleus, most require carrier proteins in the bloodstream, consist of mineralocorticoids, glucocorticoids, and stress hormones. Reproductive not stress: they are hydrophobic and most exert their effects through transcription, all of the following are true except, agonists inactivate receptors, different receptor isoforms are expressed on different cell types, receptors can be saturated at high ligand concentrations, ligand can be degraded by extracellular enzymes, ligand can make conformational changes in receptors. Intracellular receptors: hydrophobic ligand diffuses across cell membrane, binds to receptor in cytoplasm or nucleus, l r complex binds to specific dna sequences, regulates the transcription of target genes, increases or decreases production of specific mrna.
