February 7, 2014 – Biology
Malaria: purpose of their heads are to penetrate a host cell. A mosquito infected by malaria
which human host cells are the targets of infection? Liver cells ... then red blood cells. Red
blood cells: asexual reproduction. Rate of reproduction in red blood cells is similar to other red
blood cells. Malaria destroys red blood cells. Get into red blood cells and burst the cells. It’s the
host that can’t keep up creating red blood cells.
Gametocytes goes into peripheral area of the body so that mosquitos could pick them up.
Fertilization happens inside of the mosquito’s gut. Creates the Zygote – another cycle of
asexually reproduction and end up in the salivary glands.
Malaria came remain dormant in the liver. Leading cause of death is brain damage with those
who contract malaria.
Life cycle link to pathology:
• Complication due to episodes of parasite reproduction in RBC’s (shakes and chills) (3/4
o Fever – Shakes and shills – okay … 3-4 days later it is repeated.
o Mostly children and pregnant women die from brain damage
Production of ‘sticky’ infected host cells (they stick in capillaries and
eventually blocks them) (knobs)
• What does the parasite get? Spleen filters out dying and old red
blood cells. They stick in the brain to avoid the spleen to infect
• Pathology as a side-effect of parasite survival strategy
• Malaria resurgence (2 million deaths a year) (linked to global warming? Linked to poor
• Problems with vaccine development
• Sustainability approaches (head nets, bed nets)
• Treatment (chloroquine)
o Found under bark in Peru there’s a